DIGIMOUSE: A 3D Mouse Atlas

PET and Optical Simulations:

Our mouse atlas can be used to generate simulation images for PET and optical reconstructions. Here, we provide the Linear Attenuation Coefficients which were computed using the Mass Attenuation Coefficients of corresponding materials (Hubbell and Seltzer, 1996) that are assigned to the tissues in the atlas image to create an attenuation coefficient image for PET simulation.

Tissue type	Type of material	LAC(cm-1)
air	Air	1.04E-04
background	Adipose tissue	0.0913
skeleton	bone cortical	0.1717
eye	Eye lens	0.1012
medulla, olfactory bulbs, heart, lachrymal glands, bladder wall, stomach, spleen, pancreas, liver, kindeys, adrenal glands, skin	Soft tissue	0.1008
cerebellum, external cerebrum, striatum, rest of the brain	Brain	0.0994
testes	Testis	0.0993
masseter muscles	Muscle	0.0999
lungs	Lung tissue	0.0999
bladder content	Water	0.0960
tumors	Soft tissue	0.1008

Figure: Linear Attenuation Coefficients that are assigned to the tissues in the atlas image to create an attenuation coefficient image for PET simulation

For optical simulations scattering and absorption coefficients are computed using the optical properties reported in

Alexandrakis, G., Rannou, F. R., and Chatziioannou, A. F. (2005). "Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: A computer simulation feasibility study". Phys. Med. Biol., 50:4225–4241.