Warping default anatomy

Authors: Francois Tadel, John C Mosher

The best results for source localization are obtained with an individual anatomy of each subject, that are processed to extract the cortex and the scalp surface. Unfortunately, scanning a subject in an MRI costs in time and money, and may not be available for the source analysis. In this case, it was already explained in the previous tutorials that you can use the default anatomy Colin27. But for subjects that have head shapes that are really different from Colin Holme's, the localization errors can be really big.

For this purpose, Brainstorms offers an intermediate solution: Creating a pseudo-individual anatomy based on the head points that were digitized with a magnetic tracking system before the MEG acquisition. Those points really represent the shape of the head of the subject, they can be used to scale and deform the Colin27 MRI and surfaces.

Prepare the subject

We are going to test that feature in the protocol TutorialRaw, created in the tutorial ?Review continuous recordings and edit markers, because it contains a reasonable amount of head points, and it should be already in your database.

1. Select protocol TutorialRaw, and select the view "Functional data (sorted by subjects)"

2. Create a new subject "SubjectWarp". Select the option "Yes, use default anatomy" and "Yes, use one channel file per subject".

3. Copy the channel file from Subject01/(Common files) to !SubjectWarp/(Common files): Use either the keyboard shortcuts Ctrl+C and Ctrl+V, or the popup menus File > Copy/Paste.

Modifying the MRI fiducials

The fiducial points (Nasion, LPA, RPA) used in your recordings might not be the same as the ones used in the anatomy templates in Brainstorm (Colin27, ICBM, FSAverage). By default, the LPA/RPA points are defined at the junction between the tragus and the helix, as represented with the red dot in the Coordinates systems page.

If you want to use an anatomy template but you are using a different convention when digitizing the position of those points, you have to modify the default positions of the template with the MRI Viewer.

• Go to the anatomy view

• In (default anatomy), right-click on the MRI > Edit MRI

• Modify the position of the fiducial points to match your own convention
• Click on [Save], it will update the surfaces to match the new coordinate system

Check MRI/MEG registration

This process is very sensitive to the initial position of the head points relatively to the scalp surface. You really want to make sure that the alignment is correct before running the deformation of the default anatomy, and fix it if necessary.

• Right-click on SubjectWarp's channel file > MRI registration > Check.

• The grey surface is the Colin27 head surface and the green points represent the head points we digitized from the head of our subject. You can notice that the initial alignment is very bad and has to be fixed. The main reason for this bad alignment is the large difference of sizes between our subject and the Colin27 head. We do not recommend to use the automatic registration at this point, because we are trying to align those points on a completely different head shape. We are going to fix the position manually.

• Close the figure, and this time select: MRI registration > Edit.

• Use all the buttons in the toolbar to find an acceptable alignment. The head is smaller, so most of the green points should be inside the grey Colin27 surface at the end.
• You can hide the MEG helmet (first button in the toolbar) and make the head surface more transparent (use the transparency slider in the Surface tab of the Brainstorm window) if it is easier for you to see what is happening.
• The nasion/left/right fiducial points are displayed for the Colin27 anatomy (blue) and the subject (red), this is a precious information to control that you are not going too far in your re-alignment.
• Click on the OK button in the toolbar when you're done. Answer yes when you're asked to confirm the changes.

• 

Warping anatomy

Right-click on the channel file > Digitized head points > Warp > Deform default anatomy to fit these points.

• 

You get two questions asked: First the method to use:

• Scale: a simple scaling does not deform the Colin27 anatomy, it just scales it to match in size the subject's head along the three axis (x,y,w).
• Warp: this option deforms the MRI and all the surfaces of the Colin27 to match the shape of defined by the digitized head points (works only if there are enough points, and if the sampling is quite regular on the head surface).
• Select "Warp".

• 

If you have some misplaced points in your list of digitized head points, you can skip those outliers in the deformation and get a smoother results. Unless you have a lot of bad points or very few points, you can leave this default to 2% of the points.

• 

Go in the Anatomy view of the protocol (first button on top of the database explorer). All the files from the default anatomy Colin27, MRI and surfaces, have been deformed to fit the head points from the channel file of SubjectWarp.

• 

The following figures represent the anatomy before (left) and after (right). Don't worry about the alien shape of the head: the parts of the head shape that are poorly deformed (the lower part of the head) are the regions where there were no head points. What matters is the shape of the cortical surface, which looks really good in this case.

• 

You can do a final check to verify that the generated surfaces match the head points. Right-click on the channel file > MRI registration > Check.

• 

Feedback

---