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Revision 447 as of 2019-10-30 12:19:51

What's next

A roadmap to the future developments of Brainstorm.

Contents

  1. Recordings
  2. Interface
  3. Connectivity
  4. Processes
  5. Database
  6. Distributed computing
  7. Source modeling
  8. Anatomy
  9. ECOG/SEEG
  10. Statistics
  11. Input / output
  12. Distribution & documentation
  13. Current bugs
  14. Geeky programming details

Recordings

  • Sleep scoring wish list (Emily C):
    • Configurable horizontal lines (for helping detecting visually some thresholds)
    • Mouse ruler: Measure duration and amplitude by dragging the mouse.
    • Add filter option to the montage editor: This would allow splitting the signals in various frequency bands.
    • Automatic spindle detector
    • https://neuroimage.usc.edu/forums/t/page-overlap-while-reviewing-raw-file-a-way-to-set-to-0/11229/13

  • Montage:
    • Allow saving ICA results as new file using process "Apply montage"
  • RAW file viewer:
    • Downsample before filtering? (attention to the filter design)
    • Add parameter to make the visual downsampling more or less aggressive
    • Pre-load next page of recordings
    • Keep the filter specifications in memory instead of recomputing for every page
  • Bad trials: When changing the status of bad to good: remove the bad segments as well, otherwise it is not processed by processes like the PSD.
  • Review clinical recordings: Reduce the dimensionality of the data with a simple inverse problem, similar to what we do for the magnetic extrapolation ("Regional sources" in BESA, cf S Rampp)
  • MEG/EEG registration: Apply the same transformation to multiple runs
  • Create heat maps: Maybe with matlab function heatmap?

Interface

  • Add a warning when computing a forward model with > 100000 sources (check selection)

  • Snapshot: Save as image / all figures (similar to Movie/all figure)
  • Generalize the use of the units (field .DisplayUnits): Rewrite processes to save the units correctly

  • Colormaps:
    • Allow brightness/contrast manipulations on the custom colormaps
    • Global colormap max: Should get the maximum across all the open files
  • Copy figures to clipboard (with the screencapture function)
  • Smooth display from figure_image (ERPimage, raster plot...)
  • Contact sheets & movies: use average of time windows instead of single instants, for each picture.

  • Contact sheets: Allow explicit list of times in input (+ display as in MNE-Python with TS)
  • Display CTF coils: Show discs instead of squares
  • Use boundary() instead of conhull() in all the display functions (ie. 2DDisc)
  • Progress bar: Add a "Cancel" button
  • Error message: Add a link to report directly the bug on the forum
  • Reorganize menus (Dannie's suggestion): dannie_menus.png

Connectivity

  • Thresholding and stat tests the connectivity matrices
  • Connectivity on unconstrained sources: "Default signal extraction for volume grids should be the time series of the first principal component of the triplet signals after each has been zero-meaned" (SB)
  • Display of connectivity graphs:
    • Display as straight lines
    • Recode 2D graphs
    • 3D display with anatomical constrains
    • Display using real position of EEG electrodes
  • Use new band-pass filters in bst_connectivity ('bst-hfilter' instead of 'bst-fft-fir')
  • Matrix view of NxN graphs: Add legend of the elements along X and Y axis
  • Graph view:
    • Does not display negative values correctly (correlation or difference of coherence)
    • Re-write using pure Matlab code and smoothed graphics
    • Fixed scales for intensity sliders
    • Text bigger
    • Too much data in appdata
    • Fixed scales for intensity sliders
    • Add "=" shortcut for having graphs with similar configurations
    • Disable zoom in one region (serious bugs)
    • NxN on sensors: does not place the sensors correctly in space
  • Coherence:
    • Average cross-spectra instead of concatenating epochs (to avoid discontinuities)
      Explore inter-trial approaches (Esther refers to chronux toolbox)

  • Granger: Check for minimum time window (Esther: min around 500-1000 data points)
  • PLV:
    • Add p-values
    • Remove evoked
    • Optimize code
    • Add time integration
    • Unconstrained sources
    • Add warning when running of short windows (because of filters)
  • Time-resolved correlation/coherence: Display as time bands
  • Tutorial coherence [1xN] : Reproduce FieldTrip results?

  • Connect NxN: Display as time series > Display warning before trying to open too many signals

Processes

  • Decoding/Classifiers: Implement Dimitrios and scikit-learn algorithms
  • Allow processes in Python and Java
  • Add MNE-Python functions:
    • scikit-learn classifiers
    • Implement data exchange with MNE-Python: write FIF files from Brainstorm and/or pass python objects in memory instead of FIF files
    • https://neuroimage.usc.edu/forums/t/best-way-to-export-to-mne-python/12704/3

    • SSS/tSSS cleaning
    • Reproduce other tutorials / examples
    • Change the graphic renderer from Matlab
  • Add FieldTrip functions:

    • ft_sourceanalysis:
      • Check noise covariance
      • Check all the options of all the methods
      • Single trial reconstructions + noise covariance?
      • Filters?? http://www.fieldtriptoolbox.org/example/common_filters_in_beamforming

      • Beamformers: Save ftSource.avg.mom
        http://www.fieldtriptoolbox.org/workshop/meg-uk-2015/fieldtrip-beamformer-demo

      • http://www.natmeg.se/ft_beamformer/beamformer.html

      • http://www.fieldtriptoolbox.org/tutorial/beamformingextended

      • Baseline? Two inputs?
    • ft_prepare_sourcemodel: Compute MNI transformation (linear and non-linear) => Peter

    • ft_prepare_heamodel: Add support from BEM surfaces from the Brainstorm database
    • Freqanalysis: ITC
    • ft_read_atlas('TTatlas+tlrc.BRICK');
    • ft_volumereslice: http://www.fieldtriptoolbox.org/faq/how_change_mri_orientation_size_fov

    • ft_freqanalysis
    • ft_combineplanar
  • Optimization:
    • Use CUDA for speeding up some operations (filtering, wavelets, etc)
    • Use Matlab Coder to optimize: Wavelets, bandpass filter, sinusoid removal
  • Pipeline editor:
    • Bug: After "convert to continuous", the time of the following processes should change
    • Add loops over subjects/conditions/trial groups
    • Events: Allow selection from a drop-down list (similar to option "channelname" in panel_process_selection)
    • When computing sources from the pipeline editor: doesn't reselect the options if you click twice on "edit" (works for minnorm, but not for lcmv)
  • ITC: Inter-trial coherence (see MNE reports for group tutorial)
    http://www.sciencedirect.com/science/article/pii/S1053811916304232

  • ICA:
    • Why doesn't the ICA process converge when using 25 components in the EEG tutorial?
    • Add an option to resample the signals before computing the ICA decomposition
    • Exploration: Add window with spectral decomposition (useful for muscle artifacts)
    • Export IC time series (and then compute their spectrum): solves the problem above
    • Comparison JADE/Infomax:
      http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030135

    • Use faster methods (MNE-Python?)
    • Add methods: SOBI, Fastica, AMICA/CUDICA (recommended by S Makeig)
    • Dimension reduction with PCA adds artifacts: Not done by default in EEGLAB
      Contact: Stephen Shall Jones ( shall-jones@infoscience.otago.ac.nz )
      Student Carl Leichter detailed this in his thesis

    • S Makeig: Use ICA to select the IC of interest instead of only removing artifacts
    • Display of spectrum for components (PSD/FFT)
    • Import ICA matrices available in EEGLAB .set files
    • EEGLAB recommends ICA + trial rejection + ICA again: Impossible right now with Brainstorm
      (http://sccn.ucsd.edu/wiki/Chapter_09:_Decomposing_Data_Using_ICA)

    • ICA+machine learning: https://www.ncbi.nlm.nih.gov/pubmed/28497769

    • Automated artifact rejection: https://arxiv.org/abs/1612.08194

    • Save IC time series in database
    • Use EYE-EEG: EEGLAB toolbox for eye-tracker guided ICA (Olaf Dimigen): http://www2.hu-berlin.de/eyetracking-eeg/

  • Other EEGLAB functions:
    • Step function detection: https://github.com/lucklab/erplab/wiki/Artifact-Detection:-Tutorial

  • SSP:
    • Display warning if changing the ChannelFlag while there is a Projector applied

  • Spectral flattening (John):
    • ARIMA(5,0,1): Apply on the signal before any frequency/connectivity/PAC analysis
  • PSD:
    • Rewrite to have the same input as coherence (frequency resolution instead of window length)
    • Allow display of Avg+StdErr

  • Remove line noise: http://www.nitrc.org/projects/cleanline

  • Time-frequency:
    • Optimization: bst_timefreq (around l.136), remove evoked in source space: Average should be computed in sensor space instead of source space (requested by Dimitrios)
    • Short-time Fourier transform: http://www.mikexcohen.com/lectures.html

    • Matching pursuit: http://m.jneurosci.org/content/36/12/3399.abstract?etoc

    • Bug: Display logs as negative
    • Bug: 3D figures: Colormaps with "log" option doesn't work
    • Bug: Difference of power displayed in log: problems (Soheila)
    • 2D Layout in spectrum
    • Make much faster and more memory efficient (C functions coded by Matti ?)
    • TF scouts: should display average of TF maps
    • Impossible to keep complex values for unconstrained sources
    • Pad short epochs with zero values for getting lower frequencies
    • Hilbert with time bands very slow on very long files (eg. 3600s at 1000Hz) because the time vector is still full (10^7 values): save compressed time vector instead.
    • Extend clusters tab to display of TF to overlay TF signals (Svet)
    • When normalizing with baseline: Propagate with the edge effects marked in TFmask
    • Allow baseline normalization of files computed with time bands
    • Allow running TF on montages
    • Review continuous files in time-frequency space (for epilepsy)
    • Bug when computing TF on constrained and unconstrained scouts at the same time (in mixed head models for instance): uses only the constrained information and doesn't sum the 3 orientations for the unconstrained regions.
  • Artifact detection:
    • Artifact rejection like SPM: if bad in 20%, bad everywhere
    • Test difference between adjacent samples
  • Events detection: Add option "std" vs "amplitude"
  • Simulation:
    • EEGSourceSim: https://www.sciencedirect.com/science/article/pii/S0165027019302341

    • Fix units in simulation processes => no *1e-9 in "simulate recordings"

    • Use "add noise" process from Hui-Ling (in Work/Dev/Divers)
  • Use field process field "Group" to separate Input/Processing/Output options
  • Use new Matlab functions: movmean, movsum, movmedian, movmax, movmin, movvar, movstd

Database

  • Faster DB searches (for Emily)
  • Add buttons to sort files: by name, by comment, by date
  • MEG protocols: More flexible organization of the database; sub-conditions to allow different runs X different conditions.
  • Matrix files: Allow to be dependent from other files
  • Rename multiple files
  • Default headmodel lost when reloaded: Keep selection on the hard drive (in brainstormstudy.mat)
  • Auto-save:
    • protocol.mat can be too big: do not store the results links in it (and recreate when loading)- http://neuroimage.usc.edu/forums/t/abnormally-slow-behavior/2065/10

    • Improve auto-save: add tracking file next to protocol.mat, do not save all the time, only when closing app, and reload protocol at stratup if tracking file is still there

Distributed computing

  • Options from FieldTrip:

    • Loose collection of computers: https://github.com/fieldtrip/fieldtrip/tree/master/peer

    • Alternative, with less limitations: http://research.cs.wisc.edu/htcondor/

    • Single multicore machine: https://github.com/fieldtrip/fieldtrip/tree/master/engine

    • Batch system: https://github.com/fieldtrip/fieldtrip/tree/master/qsub

    • Documentation: http://fieldtrip.fcdonders.nl/faq#distributed_computing_with_fieldtrip_and_matlab

  • PSOM: http://psom.simexp-lab.org/

  • Various initiatives: http://samirdas.github.io/Data_sharing.html#/

Source modeling

  • Use eLORETA instead of sLORETA?
    https://neuroimage.usc.edu/forums/t/compute-eeg-sources-with-sloreta/13425/6

    • "eLORETA algorithm is available in the MEG/EEG Toolbox of Hamburg (METH)": https://www.biorxiv.org/content/biorxiv/early/2019/10/17/809285.full.pdf

  • Point-spread and cross-talk functions (code in MNE-Python):
    • https://www.biorxiv.org/content/biorxiv/early/2019/06/18/672956.full.pdf

    • https://github.com/olafhauk/EEGMEGResolutionAtlas

  • Dipoles:
    • Project individual dipoles files on a template
    • panel_dipoles: Doesn't work with multiple figures
  • Project sources: Very poor algorithm to project sub-cortical regions and cerebellum (algorithm to fit surfaces should be imrpoved)
  • Menu head model > Copy to other conditions/subjects (check if applicable first)

  • Menu Sources > Maximum value: Doesn't work with volume or mixed head models

  • Mixed head models:
    • Set loose parameter from the interface
  • Volume grid:
    • Optimize: 3D display (better than 9x9 cubes)
    • Optimize: vol_dilate (with 26 neighbors)
  • Menu Sources > Simulate recordings:

    • Do not close the 3D figures after generating a new file
    • Add a process equivalent to this menu
  • Panel Get coordinates: Add button "find maximum"
  • BEM single sphere: Get implementation from MNE
  • Unconstrained sources:
    • Stat and connectivity: what to do? (re-send email John+Sylvain)
  • Sources on surface: Display peak regions over time (time = color) => A.Gramfort

  • Process "Extract scouts time series": Add PCA option (replace isnorm with choice PCA/Norm)
  • Add eyes models to attract eye activity
  • Display source maps on a flat 2D cortex projection (Mollweide projection): https://neuroimage.usc.edu/forums/t/source-model-display-and-output/13940/5

Anatomy

  • Multi-Scale Brain Parcellator (Lausanne2008):
    • https://github.com/sebastientourbier/multiscalebrainparcellator

    • https://hub.docker.com/r/sebastientourbier/multiscalebrainparcellator

    • https://multiscalebrainparcellator.readthedocs.io/en/latest/

  • MNI transformation: Use SPM non-linear MNI transformation y_...
  • Registration:
    • Getting electrode positions from 3D scanners: https://sccn.ucsd.edu/wiki/Get_chanlocs

    • GARDEL: http://meg.univ-amu.fr/wiki/GARDEL:presentation

    • Use the same registration for multiple recording sessions that have already re-registered previously (eg. with MaxFilter)

    • When linking multiple EEG recordings including 3D positions, do the registration only once and copy it to all the runs
    • Compute non-linear MNI registration instead of linear
    • Select and remove bad digitized head points before automatic coregistration
    • Load the MNE -transf.fif: http://neuroimage.usc.edu/forums/showthread.php?2830

  • MRI Viewer:
    • Pan in zoomed view (shift + click + move?)
    • Zoom in/out with mouse (shift + scroll?)
    • Ruler tool to measure distances
    • Display scouts as additional volumes
    • Render surface envelope in the MRI as a thin line instead of the full interpolation matrix
      Or use inpolyhedron to get a surface mask and then erode it to get the volume envelope

    • Edit fiducials: Replace 6 text boxes with 1 for easy copy-paste (see fiducials.m)
    • Optimize computation interpolation MRI-surface (tess_tri_interp) => spm_mesh_to_grid

  • CAT12: Optimize interpolation of atlases (import is super slow...)
  • BrainSuite:

    • Add new labels to all BrainSuite anatomy templates

    • Use same colors for left and right for anatomical atlases
  • Pediatric head atlases: https://www.pedeheadmod.net/pediatric-head-atlases-v1-2/

  • Scouts:
    • Display edges in the middle of the faces instead of the vertices
    • Display scouts in a tree: hemisphere, region, subregion
    • Sort scouts by region in process options
    • Downsample to atlas: allow on timefreq/connect files
    • Project from one hemisphere to the other using registered spheres/squares (http://neuroimage.usc.edu/forums/t/how-to-create-mirror-roi-in-the-other-hemisphere/5910/8)

  • Parcellating volume grids: scikit-learn.cluster.Ward
  • Major bug when importing surfaces for an MRI that was re-oriented manually
  • Surface>Volume interpolation: Use spm_mesh_to_grid

  • Bug: Hide scouts in the preview of the grid for volume head models
  • Geodesic distance calculations:
    https://www.mathworks.com/matlabcentral/fileexchange/6110-toolbox-fast-marching

ECOG/SEEG

  • Contact positions: Import / set / detect
    • New option: Align on none|inner|cortex to replace ECOG-mid
    • Add history: Save modifications and transformations applied to the channel files (Marcel)
    • Project contact positions across subjects or templates (Marcel)
    • Add menu to import implantation channel file in imported recordings
  • Automatic segmentation of CT:
    • GARDEL: http://meg.univ-amu.fr/wiki/GARDEL:presentation

    • Arnulfo: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0511-6

    • MAP07 / SPM: https://www.epi.ch/_files/Artikel_Epileptologie/Huppertz_2_13.pdf

  • ECOG:
    • Project and display contacts on cortex surface should consider the rigidity of the grids: Contacts cannot rotate, and distance between contacts should remain constant across runs
    • Method for contacts projection: https://pdfs.semanticscholar.org/f10d/6b899d851f3c4b115404298d7b997cf1d5ab.pdf

    • ECOG: Brain shift: When creating contact positions on a post-implantation image, the brain shift should be taken into account for creating images of the ECOG contacts on the pre-op brain => iELVis (http://ielvis.pbworks.com/w/page/116347253/FrontPage)

  • Display:
    • Bad channels: Contacts greyed out instead of ignored (Marcel)
    • Display time in H:M:S
    • Display curved SEEG electrodes
  • Export list of contacts with a probability of anatomical regions from various atlases: https://neuroimage.usc.edu/forums/t/seeg-contacts-anatomical-location/14756

  • Detection CEEP stim artifacts: Use ImaGIN code ImaGIN_StimDetect

Statistics

  • ANOVA:
    • Which functions to use?
    • Write panel similar to Process1 and Process2 to allow the
    • Output = 1 file per effect, all grouped in a node "ANOVA"
    • Display several ANOVA maps (from several files) on one single figure, using a "graphic accumulator", towards which one can send any type of graphic object
  • Quality control before statistics, on condition averages across subjects:
    mean(baseline)/std(baseline): shows bad subject quickly.

  • Use SurfStat: Impements interesting things, like an analytical cluster-based p-value correction (Random-field theory which is used in SPM) - Peter

  • Export to R or SPSS for advanced stat

Input / output

  • XDF import: Use FieldTRip or the EEGLAB plugin, contact Martin Bleichner (Oldenburg)
    https://github.com/sccn/xdf/blob/master/xdf_sample.xdf

  • DICOM converter:
    • Add dcm2nii (MRICron)
    • Add MRIConvert
  • FieldTrip: Import/Export time-frequency:

    • Export: http://neuroimage.usc.edu/forums/t/export-time-frequency-to-fieldtrip/1968

    • Import: http://neuroimage.usc.edu/forums/t/import-time-frequency-data-from-fieldtrip/2644

  • 4D file format:
    • Use reader from MNE-Python: mne.io.read_raw_kit (doesn't require Yokogawa slow library)
    • Reference gradiometers: Keep the orientation of the first or second coil?
    • Reference gradiometers: Add the sensor definition from coil_def.dat
    • Validate with phantom recordings that noise compensation is properly taken into account
    • The noise compensation is considered to be always applied on the recordings, not sure this assumption is always correct
    • 4D phantom tutorial (JM Badier?)
  • EEG File formats:
    • EEG CeeGraph

    • EGI: Finish support for epoched files (formats 3,5,7)
    • XLTEK: https://github.com/danielmhanover/OpenXLT

    • Persyst .lay: https://github.com/ieeg-portal/Persyst-Reader

    • Nervus .eeg: https://github.com/ieeg-portal/Nervus-Reader

    • Biopac .acq: https://github.com/ieeg-portal/Biopac-Reader

    • gTec EEG recordings: Read directly from the HDF5 files instead of the Matlab exports.
  • BCI2000 Input (via EEGLAB plugin)
  • BST-BIN: Add compression to .bst
  • Review raw on all the file formats (ASCII EEG and Cartool missing)
  • SPM .mat/.dat: Fix the import of the EEG/SEEG coordinates
  • Get acquisition date from files: Missing for 4D

Distribution & documentation

  • Tutorial OMEGA/BIDS:
    • Add review of literature for the resting state MEG
    • Download example datasets directly from the OMEGA repository
  • New tutorials:

    • Other public datasets: https://github.com/INCF/BIDS-examples/tree/bep008_meg/

    • Rat PAC + high gamma (Soheila)
    • EEG/research
    • FieldTrip ECOG tutorial: http://www.fieldtriptoolbox.org/tutorial/human_ecog

    • FieldTrip cortico-muscular coherence tutorial: http://www.fieldtriptoolbox.org/tutorial/coherence

    • Reproduce tutorials from MNE-Python: https://martinos.org/mne/stable/tutorials.html

    • Cam-CAN database: https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess/<<BR>>(download new datasets, including maxfiltered files and manual fiducial placements)

    • MEG steady-state / high-gamma visual / frequency tagging
    • BIDS-EEG example datasets
  • Stand-alone ICA tutorial
  • Move all the files to download to the cloud for faster download everywhere in the world
  • Provide secure way of sending password over HTTPS for:
    • Account creation
    • Forum exchanges
    • org.brainstorm.dialog.CloneControl

  • Workflows FieldTrip: http://www.fieldtriptoolbox.org/faq/what_types_of_datasets_and_their_respective_analyses_are_used_on_fieldtrip

  • Count GitHub clones in the the download stats

  • Deface the MRIs of all the tutorials
  • Clean up the wiki:
    • Remove all the wiki pages that are not used
    • Check all the links in all the pages
    • Check that all the TODO blocks have been properly handled
    • Remove useless images from all tutorials
    • Update page count on the main tutorials page

Current bugs

  • Image viewer:
    • Difficult to get to 100%
    • Buggy on some systems
  • 2DLayout:
    • (TF) Units are weird with % values
    • (TF) Difficult to navigate in frequencies: Scaling+changing frequency resets the scaling
  • Progress bar:
    • Doesn't close properly on some Linux systems
    • Focus requests change workspace when processing constantly (Linux systems)
  • MacOS bugs:
    • Buttons {Yes,No,Cancel} listed backwards
    • Record tab: Text of epoch number is too big
    • Colormap menus: Do not work well on compiled MacOSX 10.9.5 and 10.10
  • in_bst_data_multi: If trials have different sizes, output is random (the one of the first file)
  • Canolty maps computation: Fix progress bar

Geeky programming details

  • bst_bsxfun: After 2016b, we can use directly the scalar operators (./ .* ...) instead of bsxfun. Update bst_bsxfun to skip the use of bsxfun when possible.
  • Interface scaling: Rewrite class IconLoader to scale only once the icons at startup instead of at each request of an icon (might improve the speed of the rendering of the tree)

  • Hide Java panels instead of deleting them
  • Processes with "radio" and "radio_line" options: Replace with "radio_label" and "radio_linelabel"
  • Interpolations: Use scatteredInterpolant, griddedInterpolant, triangulation.nearestNeighbor (2014b)
  • bst_warp and channel_project: Use tess_parametrize_new instead of tess_parametrize
  • Shared kernels: "get bad channels" operation in a different way (reading all the files is too slow)
  • Optimize bst_get:
    • Now study and subject have necessarily the same folder name
    • Replace big switch with separate functions
  • Fix all the 'todo' blocks in the code
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